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does cbd interact with prozac

Does cbd interact with prozac

“Generally speaking, you can safely use CBD supplements when you’re taking antidepressants. However, there are a couple of concerns,” Dr. Peter Grinspoon, M.D., an instructor in medicine at Harvard Medical School, and the author of the memoir Free Refills: A Doctor Confronts His Addiction, tells Bustle. “The first concern is that CBD isn’t regulated by the FDA. You have to be careful that the CBD you’re getting is from a reliable supplier. For example, Consumer Reports recently put out an article on how to go shopping for CBD because they’ve done tests, and found some [supplement] formulations had no CBD. Some were inaccurately labeled, and other formulations even had some THC in them.” (THC is the cannabis compound that, unlike CBD, can get you high.)

According to statistics from the National Alliance on Mental Illness (NAMI), one in five U.S. adults live with a mental illness in any given year. Furthermore, as NBC News reported, a 2016 study revealed one in six people in the U.S. take some type of psychiatric medication, with antidepressants being the most widely prescribed. Limited research has shown that CBD may help alleviate symptoms of anxiety and sleep issues, as well as lower levels of inflammation in the body, though this research (and the dosages needed for these effects) is nowhere near conclusive. And that means you need to be careful if you’re choosing to consume it.

The 2018 passing of the bipartisan Farm Bill legalized the production of hemp on an industrial scale for the first time in the U.S. — which means it’s that the CBD industry will only continue to grow. However, this doesn’t necessarily mean there will be more oversight or required research.

Does cbd interact with prozac

Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.

Doubling up on side effects

The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.

Does the form of CBD matter?

Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.

Does cbd interact with prozac

Numerous studies have shown that CBD can inhibit:

Below, we will discuss some important points regarding potential CBD interactions, including interactions concerning Prozac.

When A CYP enzyme is inhibited, drug concentrations can increase, due reduced metabolism. For example:

What Is CBD (Cannabidiol)?

There are no documented interactions between Prozac (fluoxetine) and CBD oil (cannabidiol). However, this is most likely due to the lack of data available as CBD has just recently begun growing in popularity as an over the counter supplement (and as a prescription product).

We have written a few articles concerning CBD drug interactions, including one with Zoloft, another SSRI like Prozac. It may be worth checking that article out for more information.

Answer

It is important to note that many of the studies that show CYP enzyme inhibition were only conducted in vitro, or in a lab/non-biological setting. There aren’t many studies that have been conducted in humans. So while there may be an indication of a potential drug interaction based on enzyme inhibition, until studies are done with specific drugs like Prozac, much is unknown.

In fact, there have been studies that postulate that while CBD does inhibit certain metabolizing enzymes, the extent of inhibition is not significant and the concentrations of CBD needed to affect these metabolizing enzymes in humans far exceeds what is possible with usual dosing.