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cbd oil for wounds

Pain associated with integumentary wounds is highly prevalent, yet it remains an area of significant unmet need within health care. Currently, systemically administered opioids are the mainstay of treatment. However, recent publications are casting opioids in a negative light given their high side effect profile, inhibition of wound healing, and association with accidental overdose, incidents that are frequently fatal. Thus, novel analgesic strategies for wound-related pain need to be investigated. The ideal methods of pain relief for wound patients are modalities that are topical, lack systemic side effects, noninvasive, self-administered, and display rapid onset of analgesia. Extracts derived from the cannabis plant have been applied to wounds for thousands of years. The discovery of the human endocannabinoid system and its dominant presence throughout the integumentary system provides a valid and logical scientific platform to consider the use of topical cannabinoids for wounds. We are reporting a prospective case series of three patients with pyoderma gangrenosum that were treated with topical medical cannabis compounded in nongenetically modified organic sunflower oil. Clinically significant analgesia that was associated with reduced opioid utilization was noted in all three cases. Topical medical cannabis has the potential to improve pain management in patients suffering from wounds of all classes.

Keywords: CBD; THC; Topical medical cannabis; endocannabinoid system; medical cannabis oil; opioid-sparing analgesia; pyoderma gangrenosum; volitional incident pain; wound-related pain.

Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

“I’m actually the first on record worldwide to start applying cannabis products to wounds to help with pain management, and now showing that it can heal the unhealable wounds in very elderly and sick patients. I’m literally healing wounds that otherwise people would be dying from or dying with… When I show the before and after pictures, people can’t believe that these results are real – but they are real!”

“The other thing that made me realize that wounds and cannabis were going to mix is that intact skin is hydrophilic, but a wound, on the other hand, is lipophilic. That kind of tissue can absorb THC and CBD which are also lipophilic. So it’s a perfect fit. This was one of my epiphany moments: that the very molecules that are anti-inflammatory in the cannabis extract are going to be able to be absorbed rapidly into a wound bed.”

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The anti-inflammatory properties of cannabinoids are driving investigations into potential therapies for an entire spectrum of disease states, and treatment for chronic wound healing is one of them.

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Anti-inflammatory, lipophilic agents

Chronic inflammation is at the heart of a non-healing wound. Normally a wound progresses through an orderly cascade of phases from the time of initial trauma until it is fully healed. As Dr. Maida explains, wounds that don’t heal get stuck in the inflammatory stage. “There’s ample pre-clinical information already published that THC and CBD and other elements of cannabis extracts have anti-inflammatory properties. My cannabinoid-based medicines are rebooting the wound out of that chronic inflammatory stage.”