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cbd oil for elderly

There are practical concerns regarding CBD use in older adults. The geriatric population may be more susceptible to adverse effects of CBD commonly seen in younger adults, including sedation. CBD is hepatically metabolized, predominantly via CYP2C19 and CYP3A4. 4 Older adults with reduced hepatic function may be more susceptible to adverse effects of CBD.

Endogenous cannabinoids and phytocannabinoids such as CBD and THC modulate the endocannabinoid system (ECS). THC is a partial agonist on the cannabinoid (CB) 1 receptor that results in central nervous system (CNS) effects, such as the “high” associated with marijuana; it also has limited CB2 agonist activity in the immune system. CBD has minimal activity on CB receptors, but it affects the ECS and the non-ECS. 4 Some of the proposed mechanisms of CBD include agonist activity at serotonin 1A, transient receptor potential vanilloid 1, G protein–coupled receptor 55, and adenosine A2A receptors, which may explain some of the possible analgesic, anti-inflammatory, anxiolytic, and antiepileptic effects of CBD. 1,5

Other Disease States: Data on the use of CBD for various other conditions are mixed, and evidence is insufficient to recommend this practice. The efficacy of CBD has been studied in bipolar disorder, Crohn’s disease, diabetes, dystonia, fragile X syndrome, graft-versus-host disease, Huntington’s disease, opioid withdrawal, Parkinson’s disease, schizophrenia, and smoking cessation. 33 In addition, CBD has been reported to be useful for addiction, possibly by modulating dopamine and serotonin. 1

Pain: An estimated 50 million American adults (20.4%) experience chronic pain, with persons aged 65 years and older constituting 61.2% of those affected. 24 Much of the data on chronic pain (e.g., neuropathic pain, cancer pain, diabetic peripheral neuropathy, fibromyalgia, HIV-associated sensory neuropathy, spasticity associated with multiple sclerosis [MS], and rheumatoid arthritis) involve the use of marijuana and cannabinoids (often THC, combination THC-CBD, or nabiximols [a specific mixture of THC, CBD, other minor cannabinoids, flavonoids, and terpenes]). Formulations used in pain studies range from smoked, oral, or oromucosal spray of THC; synthetic cannabis (nabilone); synthetic THC (dronabinol); and vaporized cannabis, with results suggesting modest reductions in pain and spasticity. 25

Drug-Drug Interactions

Anxiety: Evidence is not strong for the use of CBD for anxiety disorders. CBD has demonstrated some benefit for social anxiety disorder and social phobia when patients undergo a simulated public-speaking test. 31,32 However, these trials had small sample sizes and study biases. It is theorized that CBD could be beneficial for anxiety based on its mechanism of action at the serotonin receptor. 31

32%), decreased appetite (16%-22%), diarrhea (9%-20%), and increased liver-function tests (13%). 7 Other side effects are orthostatic hypotension, lightheadedness, and dry mouth. Adverse effects appear to be dose-related. The safety of CBD in the geriatric population has not been fully clarified, and Epidiolex clinical trials did not include patients older than 55 years. 7

Absorption of CBD may also be altered by food intake. In clinical trials, coadministration of Epidiolex with a high-fat, high-calorie meal increased plasma levels of CBD fourfold to fivefold compared with administration on an empty stomach. 7 In one study using a purified (99%) CBD capsule, coadministration with food resulted in a maximum concentration and AUC of 14-fold and fourfold higher, respectively, compared with administration on an empty stomach. 22 CBD inhalation in humans has an average bioavailability of approximately 31%, with the use of one type of metered-dose inhaler demonstrating bioavailability of more than 65%. 18,23 Transdermal absorption of CBD is variable in animal studies and has yet to be fully elucidated in humans. 4

Formulations

The use of CBD is considered “possibly safe” when used appropriately, based on some clinical evidence. 33 However, insufficient high-quality data exist to recommend CBD for most older adults. The most common adverse effects associated with CBD, reported in clinical trials of Epidiolex, are somnolence (

Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) are among the many cannabinoids, or components, of the Cannabis sativa plant. CBD is nonpsychoactive, whereas THC has psychoactive properties such as euphoria and psychosis. Two common strains of Cannabis sativa are marijuana and hemp. 1 CBD may be derived from either marijuana (which often contains more than 15% THC) or hemp (having a THC concentration of no more than 0.3%). 2 In addition, CBD may be extracted from Cannabis indica and hybrid plants, which may have higher concentrations of CBD than THC. A recent survey revealed that one in seven Americans uses CBD products, with the most common reasons for its use being pain, anxiety, poor sleep, and arthritis. 3

Read the label. Always read the label of any CBD product to check for additional ingredients that could affect your health or safety.

In short, CBD has been proven effective in enhancing the quality of life, preventing cognitive decline, reducing blood pressure in stressful situations, and more.

When something is out of balance, like an inflamed joint due to arthritis or injury, CBD oil helps support your endocannabinoid system so your body can better handle and relieve the problem.

Benefits of CBD Oil

CBD also carries some potential risks and may cause:

General anxiety and performance anxiety. One study of individuals with a social anxiety disorder and fear of public speaking gave some people a single dose of CBD an hour and a half before they participated in public speaking. Those given the CBD experienced a significant reduction in their anxiety, with less discomfort and stress.

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Journal of pain and symptom management: “Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.”

Your body works best when everything is balanced, and your endocannabinoid system helps maintain that balance, despite what might be going on in your external environment.

Cannabis could provide a great need for the elderly as it relates to bone fragility. According to a study, cannabis use can help heal fractures and support healthier bones. Because of its anti-inflammatory properties, cannabis can be very useful for patients with multiple sclerosis.

A general, dangerous health hazard among older citizens is the loss of appetite, which causes weight loss, tissue weakness, and mental issues. While marijuana has been extensively researched, and shown to improve the appetite of users, CBD likewise has proven to be a good appetite stimulant and thus helpful for seniors.

3. Soothing Effects

In addition, CBD is an antioxidant that promotes the sense of vigilance that can be disturbed by the presence of free radicals. A study shows that cannabidiol has stronger antioxidant properties than Vitamin C and Vitamin E.

There has been growing research that supports a link between cannabis and the treatment of glaucoma. Glaucoma, which is a neurodegenerative disease (the breakdown of neurons in the communication process from the brain to the body), affects the sight of individuals from an increase in pressure in the eye known as intraocular pressure (IoP). Going back decades, there is supporting evidence that cannabinoids can reduce IoP by up to 25%, however the required dosage of inhalation of full THC cannabis has posed a risk to some patients. However, due to the accompanying symptoms of glaucoma, CBD as a pain management product works well, and may have the added benefit of helping reduce pressure.

7. Stimulates Appetite

An emerging trend that is being researched is could marijuana prevent the onset of Alzheimer's disease. According to multiple studies, cannabinoids, and by extension CBD, can contribute to the elimination of a toxic protein related to this disease. This is triggered by a loss of inflammation of the brain and regeneration of damaged cells.