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cbd for bones

Chalk another one up for medicinal marijuana. With legalization sweeping the nation, interest in weed’s therapeutic properties is at an all-time high. It’s already being used to treat cancer patients and people with Parkinson’s disease, and it’s recently been proposed as a treatment for PTSD. Now, researchers have found that one component of pot can actually be used to mend fractures.

Before you go there, the answer is no, smoking a joint won’t heal a broken bone. The researchers from Tel Aviv University found that one of marijuana’s non-psychotropic components — the cannabinoid know as cannabidiol — can enhance the bone healing process, at least in rats. In their study, which was recently published in the Journal of Bone and Mineral Research, the scientists isolated cannabidiol from its highly psychoactive cannabinoid cousin, THC, and injected it into rats with broken thigh bones. They found that cannabidiol alone was enough to enhance bone healing in just eight weeks.

“The clinical potential of cannabinoid-related compounds is simply undeniable at this point,” Gabet said. “While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis. CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity.”

Purpose of review: Here, we overview the latest findings from studies investigating the skeletal endocannabinoid (EC) system and its involvement in bone formation and resorption.

Recent findings: The endocannabinoid system consists of endogenous ligands, receptors, and enzymes. The main cannabinoids found in the cannabis plant are Δ 9 -tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate bone homeostasis in rodents and humans. CBD treatment was shown to enhance fracture healing in rats. Recent studies in mice indicate that strain, age, and sex differences dictate the skeletal outcome of the EC activation. CBD treatment was shown to enhance bone healing, but needs validation in clinical trials. While research shows that EC activity protects against bone loss, studies on CB1 and CB2 agonists in bone regeneration models are lacking. Whether modulating the EC system would affect bone repair remains therefore an open question worth investigating.

Keywords: Bone; CB1 receptor; CB2 receptor; CBD; Cannabinoid; Cannabis; Endocannabinoid; Fracture; Osteoporosis; Skeleton.

Observations throughout the study demonstrate that the CB1 receptor regulates peak bone mass through effects of osteoclasts, bone resorption and age-related bone loss. This means that the administered CBD helped to strengthen the fracture callus; the cartilage which mends the fracture. The CB1 receptor is therefore unique in that it regulates peak bone mass through an effect on osteoclast activity, but protects against age-related bone loss by regulating bone cells.

Once you get older your bone will begin to deteriorate causing your bones to become brittle, making it easier to fracture. Old age can also come with bone diseases that create a block in bone growth. Getting through life with a bone disease like osteoporosis typically means relying on medications to provide relief. Prescription medications can come with harsh side effects that make you feel even worse. Turning to a natural cannabinoid will eliminate having to take medications that provide poor side effects. Research shows direct correlation in CBD and bone growth.

How a Bone Fracture Heals

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Once the fracture has occurred one will experience a inflammation stage where a blood clot will form. Cytokines then begin to repair cells into the fracture gap. These cells will turn into specialized cells to create osteoblasts which produce new cells that lay down new bone and cartilage. These osteoblasts produce protein to create a soft callus which will harden over time. Finally as the bone fully heals osteoblasts and osteoclasts will weave the bone with bone formation cells and bone resorption cells. During this process the bone will rebuild itself.

CBD and Bone Growth Research

Breaking a bone and waiting for it to heal correctly is a long process that takes patience. Research shows that cannabinoids, including CBD, increase the bone growth but also bone density. This is all because of the endocannabinoid system. Cannabinoids work on receptors in the endocannabinoid system to produce bone formations. Research even shows that we have a skeletal endocannabinoid system that works directly with our bones.