Posted on

cbd for bladder cancer in dogs

Cbd for bladder cancer in dogs

Hocker’s study focuses on three different cell lines from canine bladder tumours. The cell lines will have CBD applied to them to look at whether CBD will kill the cells alone and whether it works better or worse with chemotherapy and/or radiation.

That year, Statistics Canada said, Canadian households spent $8.23 billion in total on pets, their food, related services and veterinary care, up from the $6 billion spent on the same items in 2013.

University of Guelph is studying the efficacy of using cannabis for treating urothelial carcinoma tumours in dogs.

“What we don’t have however, is a substantial amount of published studies showing the effects of cannabis on treating common conditions in the animal species that we have as companion animals — namely dogs, cats and horses,” she said.

Vets started Red, who has yet to lose his energy or any weight, on radiation, but plenty of Chorney’s friends with elderly dogs had a treatment of their own to suggest — cannabis.

“Certainly the single, largest driving force is the demand from pet families,” Dr. Sarah Silcox, the president of the Canadian Association of Veterinary Cannabinoid Medicine, told the Star in an email.

Fig 4. Combinations of CBD with mitoxantrone or vinblastine induces increased early apoptosis.

Fig 2. Combination treatment of CBD with…

Results: Cannabidiol reduced cell viability and induced apoptosis in canine urothelial cells as determined by crystal violet viability assay and annexin V/propidium iodide flow cytometry. Furthermore, combinations of cannabidiol with mitoxantrone and vinblastine chemotherapy yielded significantly reduced cell viability and increased apoptosis compared to single agent treatment alone. The drug interactions were deemed synergistic based on combination index calculations. Conversely, the combination of cannabidiol and carboplatin did not result in decreased cell viability and increased apoptosis compared to single agent treatment. Combination index calculations suggested an antagonistic interaction between these drugs. Finally, the combination of the non-steroidal anti-inflammatory drug piroxicam with cannabidiol did not significantly affect cell viability, although, some cell lines demonstrated decreased cell viability when mitoxantrone was combined with piroxicam.

Fig 2. Combination treatment of CBD with mitoxantrone, vinblastine, or carboplatin in canine urothelial carcinoma…

Conflict of interest statement

Fig 5. Polygonogram showing drug interactions of…

Background: Canine urothelial carcinoma is the most common form of canine bladder cancer. Treatment with chemotherapy has variable response rates leading to most dogs succumbing to their disease within a year. Cannabidiol is an emerging treatment within the field of oncology. In reported in vivo studies, cannabidiol has induced apoptosis, reduced cell migration, and acted as a chemotherapy sensitizer in various human tumor types. The aim of this study was to characterize the effects of cannabidiol on canine urothelial carcinoma cell viability and apoptosis as both a single agent and in combination with chemotherapy in vitro.

Fig 1. Dose-dependent decreases in cell viability with carboplatin, mitoxantrone, vinblastine, and CBD treatment of…


Fig 4. Combinations of CBD with mitoxantrone…

Conclusions: Cannabidiol showed promising results as a single agent or in combination with mitoxantrone and vinblastine for treatment of canine urothelial carcinoma cells. Further studies are justified to investigate whether these results are translatable in vivo.

Cbd for bladder cancer in dogs

Since the cancer isn’t the only type of canine cancer that disrupts the natural urination of dogs, canine cancer specialists have to rule out all the other possibilities. That’s why diagnosing urinary tract cancer in dogs is not a straightforward process. Here are some examples of the types of testing your dog might undergo before officially being diagnosed with bladder cancer.

Sara Redding Ochoa, DVM was raised in north Louisiana. She graduated from LA Tech in 2011 with a degree in animal science. She then moved to Grenada West Indies for veterinary school. She completed her clinical year at Louisiana State University and graduated in 2015 from St. George’s University. Since veterinary school she has been working at a small animal and exotic veterinary clinic in east Texas, where she has experience treating all species that walk in the hospital. In her free time, she likes to travel with her husband Greg, bake yummy desserts and spend time with her 4-legged fur kids, a dog Ruby, a cat Oliver James “OJ”, a rabbit BamBam and a tortoise MonkeyMan.

The pacing is a dog’s way of trying to relieve their discomfort, but it’s to no avail. On top of odd bathroom behaviors, your dog might stop pooping altogether, too. This is primarily because they aren’t consuming much food. This means there’s nothing to excrete as waste. Blood in the urine is likely going to be a frequent occurrence, too.

How Bladder Cancer in Dogs is Diagnosed

There are many different treatment options for canine bladder cancer. Your dog’s vet will recommend certain treatment options depending on the state of your dog’s disease and the severity of the symptoms. Some dogs will undergo a biopsy, and others might need the malignant tumor to be surgically removed.

To diagnose this disease in dogs, veterinarians must perform a series of tests to rule out other possibilities like urinary tract infections. With the symptoms that the disease causes, it’s relatively easy for specialists to pinpoint the bladder as being in the general vicinity of the problem, but it’s not always apparent that the problem is the disease itself.

Some people will say that they are too similar to be their own separate diagnoses, but slight differences revolve around the origin of the cancer cells. Whether you consider them to be one type of bladder cancer or two, the most common type of this disease in dogs is transitional cell carcinoma.

How Long Can a Dog Live with Bladder Cancer?

Many types of canine cancer have a general list of symptoms that could appear at any point, no matter which stage of cancer your dog has. This cancer of the bladder is a little different because each stage has its own set of symptoms. The general theme of the issues that arise is that this cancer fully impacts a dog’s urinary system which causes straining to urinate like a normal, healthy dog.

It’s always essential to casually take a look at your dog’s urine every once in a while to make sure everything looks normal and healthy. Blood in the urine is indicative of bladder cancer, so checking your dog’s urine might clue you into the possibility that bladder cancer is the culprit behind your dog’s odd bathroom behavior.