Furthermore, a 2019 study 7 points out that while the use of CBD for several diseases is growing, it lacks sufficient scientific evidence to prove its efficacy.
Reference from anecdotal evidence from a patient suffering from MD reports that after administering CBD oil sublingually, the severity of MD went down. The patient observed improvements in her condition from Intermediate MD to an early stage of MD.
In this lineup, the ocular route delivers desired cannabinoids through the eyes.
CBD drops and eye dryness
There is little to no reference about the use of CBD in its oil formulation for topical eye applications. The above reference from several studies that we have discussed has highlighted the implications of the use of CBD on eye pressure. But there is no specific mention of CBD oil.
1.The 2018 study 5 tested and compared the results of IOP on rats after independently administering eye drops containing THC and CBD.
In such a case, do cannabinoids infused eye drops meet these expectations? What novelties are adopted in drug delivery to improve efficacy and relief in affected populations?
CBD Eye drops for macular degeneration
But, contradicting the above reference, a 2017 study 2 points out that lipophilic drugs are absorbed well through the cornea, whereas both lipophilic and hydrophilic compounds are well able to penetrate through the conjunctiva and sclera.
From the above discussions, we can perceive that research so far shows mixed results on the effect of CBD eye drops. Also, research in this area is complicated, expensive, and time-consuming. Therefore, it is hardly possible to arrive at any conclusion if CBD as eye drops are safe to use.
The study, coupled with other research using human subjects, “raises a legitimate concern about whether CBD may raise eye pressure and so serve as a potential risk factor for glaucoma,” said lead researcher Alex Straiker, an associate scientist in the university’s Department of Psychological and Brain Sciences.
Straiker said in an email that the researchers also discovered that CBD actually cancels out the eye-pressure-lowering effects of tetrahydrocannabinol (THC), the primary psychoactive ingredient of marijuana.
by Patrick J. Kiger, AARP, January 24, 2019
A recent study suggests that the marijuana product might worsen the condition
The group cited a study by Indiana University researchers, published in December in the journal Investigative Ophthalmology & Visual Science. The researchers found that mice that were given eye drops containing a CBD extract experienced an 18 percent increase in pressure inside the eye (a hallmark of glaucoma) at least four hours after dosage.
En español | Cannabidiol, or CBD, a chemical component of marijuana and hemp that doesn’t get users high, is increasingly touted by proponents as an alternative treatment for numerous ailments. But an organization of eye doctors is advising people not to try CBD as a remedy for glaucoma, a disease for which older Americans are at higher risk.
“Don’t use CBD as a ‘natural’ glaucoma remedy," the American Academy of Ophthalmology warned in a press statement pegged to Glaucoma Awareness Month.
Glaucoma, which can cause blindness, affects people of any age, but those 40 and older have a higher risk, according to the eye doctor group.