Posted on

average cbd percentage

As far as drug interactions go, there hasn’t been a ton of research and testing, so it’s hard to say. CBD can potentially interfere with tacrolimus , an immunosuppressive medication. Because there are a lot of unknowns, anyone looking to supplement their current medications with CBD should consult a healthcare provider first.

Additionally, the FDA has not approved products that contain cannabis or cannabis-derived compounds for medical use. In fact, at the federal level, all marijuana is illegal (medical or otherwise). It’s still classified as a Schedule I substance (along with heroin and LSD) by the DEA under the Controlled Substances Act . However, 33 states have legalized it for medical purposes, and 11 of those have approved recreational use for adults 21 and older. Technically, federal law supersedes state law, but the federal government has not chosen to prosecute businesses and/or individuals selling or using cannabis in states where it’s been legalized.

Marijuana and hemp each contain both compounds but in different ratios. Hemp has much lower levels of THC and larger amounts of CBD, which is why it’s often used for CBD products. Marijuana, on the other hand, has significantly more THC.

CBD questions and answers

The CBD market exceeded $4 billion in 2019, according to a study by the Brightfield Group, and they expect the industry to top $25 billion by 2025.

CBD use is most common in populations ages 18-34, according to a recent SingleCare survey.

People tout CBD as a miracle treatment for heart disease, cancer, autoimmune diseases, Alzheimer’s, acne, and much more. Researchers haven’t found substantial evidence that it can effectively treat any of these conditions, but we also know that inflammation and stress can be contributing factors to these conditions. So, there may be some truth to the claims that CBD is beneficial to everyday health. Whether it’s in a morning smoothie, part of a skincare routine, or something else entirely, regular CBD use can potentially be beneficial for some people, although it comes with risks too.

Why do people use CBD?

According to our SingleCare survey, nearly half of CBD users prefer oils/tinctures, lotions/balms, and gummies. But there’s a growing market for CBD edibles.

Like other medications, CBD can have side effects, too. In one study , one-third of CBD users reported a non-serious side effect, including dry mouth, euphoria, hunger, irritated eyes, and/or fatigue. And according to Michael Hall, MD, the founder of the Hall Longevity Clinic , the spectrum of side effects is even broader.

The analytical method has been previously described (3). Briefly, a Varian gas chromatograph with Flame Ionisation Detector (GC/FID) is used for the analysis. Quantitative analysis of seven of the major cannabinoids in cannabis (Δ 9 -Tetrahydrocannabinol, Δ 9 -THC; Δ 8 -Tetrahydrocannabinol, Δ 8 -THC; Tetrahydrocannabivarin, THCV; Cannabidiol, CBD; Cannabichromen, CBC; Cannabigerol, CBG and Cannabinol, CBN) is carried out by solvent extraction followed by analysis using capillary gas chromatography, a method offering short analysis time and resolution of all cannabinoids on a single column. Two samples (100 mg each) are used for analysis from each manicured potency monitoring (PM) sample. A 3.0 ml of internal standard (I.S.) extraction solvent (100 mg of 4-androstene-3,17-dione + 10 mL chloroform + 90 mL methanol) is added to the sample and allowed to rest at room temperature for one hour. The extract is then filtered through a cotton plug and the clear filtered material is transferred to an autosampler vial. Samples are placed onto the GC instrument along with vials of ethanol, internal standard/Δ 9 -THC mixture (unextracted standard), and controls. Lastly the results are calculated by obtaining an average percentage of each cannabinoid from the two chromatograms of each PM sample. It must be noted that the response factor for the cannabinoids relative to I.S. is 1. Therefore, the area of each cannabinoid divided by that of the I.S. multiplied by the amount of I.S. added (3 mg) gives the percentage of each cannabinoid in the sample, since 100 mg of sample is used for analysis. For example, a cannabinoid with the same peak area as that of the I.S. represents a 3% concentration in the sample. The method has been validated to meet FDA (food and drug administration) GMP (good manufacturing practices) requirements.

In this review the focus will be on the status of the cannabis potency in the United States, since this is where the bulk of potency data has been generated. Furthermore, while previous potency reports from our group have included data from samples provided from the Federal Drug Enforcement Administration (DEA) seizures as well as samples provided by state law enforcement agents through the cannabis eradication program, this review will focus on potency trends using only the DEA seized materials. These samples actually provide more realistic data since the seizures are made as the materials were on the way to illicit market distribution. While the main cannabinoids of interest in cannabis are THC and CBD, analysis is carried out for all major cannabinoids to have a good understanding of the chemical profile of all samples which might affect the overall biological activity of the drug.

In our last potency trends publication (4) we reviewed the status of cannabis potency in the illicit market, not only in the United States (USA), but also in Europe and other countries around the world. The data from the USA was based on our own findings, ending in 2009, while the other countries’ data are based on literature reports. While the potency of cannabis has increased dramatically over the years, resulting in negative impact on the users (6), it is important to mention that the literature is rich with many studies showing efficacy and biological activity of therapeutic potential using much lower potency cannabis preparations (ranging from 1.5-4% THC).

The statistical analysis of data was performed using normal distribution function (NORM.DIST) of Microsoft Excel.

Table 2

Hash Oil – Obtained from the cannabis plant by solvent extraction, and contains the cannabinoids present in the natural oils of cannabis flowers and leaves. The solvents are evaporated to leave behind very concentrated oil.

Hashish – A concentrated resin cake or ball produced from pressed kief, the detached tricomes and fine material that falls off the cannabis flowers and leaves. It varies in color from black to golden brown depending on the purity and variety of cultivar it was obtained from.

Marijuana is the most widely used illicit drug in the United States and all over the world. Reports indicate that the potency of cannabis preparation has been increasing. This report examines the concentration of cannabinoids in illicit cannabis products seized by DEA (drug and enforcement administration) over the last two decades, with particular emphasis on Δ 9 -THC and cannabidiol (CBD).


Ditchweed – Unattended, wild male and female fiber type cannabis (hemp) that is native to many mid-western states.

Kilobrick – Pressed cannabis made of leaves, heads, stems, and seeds.